摘要
目的 观察拓扑替康联合顺铂治疗晚期非小细胞肺癌的近期疗效。方法 拓扑替康 1mg/m2 ,静脉点滴 ,第 1～ 5天 ;PDD 3 0mg/m2 ,静脉点滴 ,第 1～ 3天。每 2 1天为 1个周期 ,连用 2个周期后评价疗效。结果 CR 2例 ,PR 13例 ,总有效率CR +PR 5 3 6%。本方案主要的毒副反应是骨髓抑制和胃肠道反应。结论 拓扑替康联合顺铂是一个安全、有效的治疗晚期非小细胞肺癌的临床方案。
Objective To observe the recent effect of combination chemotherapy with topotecan(TPT) and cisplatin(PDD) in the treatment of patients with advanced non_small cell lung cancer.Methods Topotecan(TPT) was 1 mg/m 2 ivgtt,d1～5. PDD was 30 mg/m 2 ivgtt,d1～3.The schedule was repeated every 21 days, with at least two cycles.Results The complete response was observed in 2 cases, and partial response was observed in 13 cases. The overall response rate (RR) was 53.6%. The major toxicities were myelosuppression and gastrointestinal reaction.Conclusion The regimen is effective and safe in the treatment of patients with advanced non_small cell lung cancer.
出处
《河南肿瘤学杂志》
2004年第1期39-40,共2页
Henan Journal of Oncology
