摘要
原发性高血压14例(男11例,女3例;年龄54±s4a),首次口服尼群地平20mg2-3h后,消除T_(1/2)为3.8±1.4h,T_(max)4.4±1.5h,总外周阻力、平均动脉压分别下降40％,20％,降压作用持续12h。尼群地平10-20mg,qd或bid,口服3-4wk后,血压仍有明显下降(P<0.05),且对心率、心排血量、血糖、酯质代谢及肝、肾功能等无明显影响,适用于老年患者。
Fourteen patients (M11, F 3; age 54+s4a) with essential hypertension received nitrendipine po 2-3 h after the initial dose of 20 mg, results showed that 7B 3.8+1.4h, Tmax 4.4+1.5 h, total peripheral resistance and mean arterial pressure were reduced by 40%, 20% respectively, and were maintained for 12 h; and 3-4 wk after 10-20 mg qd or bid, the hypotensiye effect was maintained (P<0.05). It had no obvious effects on heart rate, cardiac output, glucose, lipid metabolism,' hepatic and re-rial function. It is suggested that nitrendipine is suitable for hypertension in aged.
出处
《新药与临床》
CSCD
北大核心
1992年第6期346-349,共4页
关键词
尼群地平
高血压
药物动力学
nitrendipine/therapeutic use
hypertension/drug therapy
pharmacokine-tics
