摘要
对神经阻滞剂所致静坐不能40例男性患者,年龄17-60a(30±13a),用普萘洛尔和苯海索进行双盲交叉试验。普萘洛尔30-120mg/d,苯海索4-16mg/d,po,疗程2wk.采用修改的Simpson锥体外系副作用量表评定疗效,以苯海索为对照药。结果表明2药疗效相似,苯海索副作用显著高于普萘洛尔。
Forty male patients aged 17-60 a (30+13 a) with neuroleptic-mduced akathisia were treated with propranolol and trihexyphenidyl by the double-blind crossover trial. The dosages of oropranolol were 30-120 mg/d, that of trihexyphenidyl were 4-16 mg/d, po for 2 wk. The clinical efficacy were assessed by modified Simpson's extrapyramidal side effect rating scale. Trihexyphenidyl was taken as the control. The results showed that the efficacies of the two drugs were almost the same. The side effects of trihexyphenidyl were much higher than that of propranolol.
出处
《新药与临床》
CSCD
北大核心
1992年第6期322-323,共2页
关键词
普萘洛尔
苯海索
运动障碍
propranolol/therapeutic use
trihexyphenidyl/therapeutic use
drug induced dvskinesia
