摘要
6名受试者口服氧氟沙星400mg后,药-时曲线符合一室开放模型。T_(max)和C_(max)分别为1.3h和4.4μg/mL,T_((1/2)ka),T_((1/2)ke)分别为0.8和3.7h,C1为0.36L/(h·kg),V_d为1.9 L/kg。该药对革兰阳性或阴性细菌均有高度抗菌活性,对变形杆菌、痢疚杆菌、大肠杆菌、枸橼酸杆菌、伤寒杆菌和金葡菌等的抑菌率均>90％。
Six healthy volunteers were given po ofloxacin (OFX) 400 mg, the serum drug concentrations were determined by reverse-phase HPLC to study its pharma-cokinetic characteristics. Antimicrobial activities of OFX in vitro to 918 strains isolated from patients were also examined. The results showed that OFX (had excellent antibacterial effect to almost all of Gram-positive and Gram-negative organisms. The inhibition rates were over 90% for most of the strains. After oral administration, the serum concentration-time profile of OFX conformed to the one compartment open model. Tmax and Cmax were 1.3h and 4.4ug/mL, respectively. T1/2ka and T1/2ke were 0.8h and 3.7h, respectively. Cl was 0.36L/(hkg). Vd was 1.9L/kg. These data showed that the drug was widely distributed in the tissue and body fluid.
出处
《新药与临床》
CSCD
北大核心
1992年第5期258-260,共3页
关键词
氧氟沙星
药物动力学
高效液相色谱
ofloxacin
pharmacokiuetics
high pressure liquid chromatography
