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抗药基因MGMT在人脑星形细胞瘤组织中的表达 被引量：2

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摘要 6位甲基鸟嘌呤-DNA甲基转移酶(O6-methylguanine-DNA methyltransferase,MGM T)主要功能是转移并接受DNA双链中鸟嘌呤O6位上异常的烷基,使受损的DNA恢复正常[1].我们检测了MGMT基因在人脑胶质瘤的表达情况,探讨MGMT表达对人脑星形细胞瘤的意义.
作者 赵文元 周晓平 刘建民 姜秀峰 卢旺盛 刘善荣
机构地区 第二军医大学长海医院神经外科 基础医学部组织胚胎学教研室
出处 《药学服务与研究》 CAS CSCD 2001年第1期18-18,24,共2页 Pharmaceutical Care and Research
关键词 星形细胞瘤 抗药性 基因表达调控 肿瘤 甲基转移酶类
分类号 R730.263 [医药卫生—肿瘤]
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参考文献5

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同被引文献40

  • 1张晓红,张福荣,籍秀娟,李占荣.KB细胞耐药株的建立及其耐药机制的探讨[J].药学学报,1994,29(4):246-251. 被引量：63
  • 2王明盛,杨正明,陈坚.卡铂、威猛、甲氨蝶呤、尼莫地平联用对脑胶质瘤的抑制作用[J].山东医药,2005,45(10):22-23. 被引量：5
  • 3顾科,张军宁.成人Ⅱ级以上脑胶质瘤术后同步放化疗疗效分析[J].肿瘤防治研究,2007,34(8):626-628. 被引量：13
  • 4Feun KA, gyre HJ, Townsend JJ, et al. Correlation of tumor 06- methylguanine- DNA methytransferase levels with survival of malignant astrocytoma patients treated with bischoroethylnitrosourea: a Southweast Oneology Group study. J Clin Oncol,1998,16:3 310-3 351.
  • 5Silber JR, Mueller BA, Ewers TG, et al. Comparison of 06-methylguanine-DNA methytransferase activity in brain tumors and adjacent normal brain. Cancer Res, 1993. 53:3416-3120.
  • 6Mineura K, Yanagisawa T, Watanabe K, et al. Human braintumor 06 - methylguanine- DNA methytransferase mRNA and its significance as indicator of selective chloroethy lni trosourea chemotherapy. Int. J. Cancer, 1996,69:420-425.
  • 7Preuss I, Eberhagen I, Hass S, et al. 06-methylguanine- DNA methytransferase activity inbr, east and brain tumors[J]. Int J Cancer. 1995 ,61(3):478.
  • 8Silber JR, Blank A. Bobola sin, et al. I.ack of the DNA repair protein 06-methylguanine-DNA methytransferase in histologically normal brain adjacent to primary human brain tumors[J].Proc Natl Acad Sci USA, 1996,93(14) :545.
  • 9Mineura K, Izumi I, Watanabe K, et al. Enhancing effect of 06-alkylganine derivativeson chloroethylyni-trosourea cytotoxicity toward tumor cells[J]. J Cancer, 1994,58(8) :856.
  • 10Hongeng S, Brent TP, Sanford RA, et al. Rapid. 06 - methylguanine-DNA methytransferase protein levels in pediatric brain tumors[J]. Cancer Res, 1997,3 (12Pt1) : 278.

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药学服务与研究
2001年 第1期

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