摘要
目的观察重型肝炎肝功能衰竭患者血清总胆汁酸(TBA)水平变化,探讨其在病情发展过程中的作用。方法循环酶速率法,检测重型肝炎肝功能衰竭患者TBA水平。结果①重型肝炎肝功能衰竭患者TBA水平高于对照组,经统计学检验差异有显著性意义(P<0.01)。②重型肝炎患者进展期血清TBA异常率与其他肝功能指标异常率比较,TBA与ALT(丙氨酸氨基转移酶)、TBIL(血清总胆红素)异常率均为100％。③恢复期血清TBA及其他肝功能指标值下降幅度比较,血清TBA与ALT下降幅度均大于90％,而AST(天冬氨酸氨基转移酶)、ALP(碱性磷酸酶)、GGT(谷氨酰氨转移酶)及ALB(血清白蛋白)指标在45％～54％之间。结论重型肝炎肝功能衰竭患者存在胆汁酸代谢异常;血清TBA也是肝功能严重受损敏感的指标;血清TBA与ALT一样是反应肝细胞功能恢复及病情好转的敏感指标。血清TBA测定在重型肝炎肝功能衰竭的病情进展的判断、疗效观察方面有重要意义。
Objective To observe the level of serum total bile acids and evalute its predicting value in patients with severe hepatitis and hepatic failure.Methods To letect the level of serum total bile acids capacity in patients with severe hepatitis and hepatic failure with kinetic method. Results The level of total bile acids in patients with severe hepatitis was jogjer than that in the normal controls.The difference was statis-tically significant.The abnormal rate of TBA (the total bile acids) and ALT (Alamome amomotransferase) and TBIL (total bilirubin) in the deterioration phase was all 100% .The descent extent of TBA and ALT in the recovery phase was more than 90%, while that of AST (Aspartate aminotransferase)、ALP (Alkaline phosphatase)、GGT (Gamma glutamyl transferase) and ALB (albuminate) was between 45% and 54%
.Conclusions The metabolism of TBA is abnormal in patients with severe hepatitis. TBA is a sensitive index, not only to reflect the damage of the
liver function) but also to reflect the recovery of hepatocyte and improvement of the patients condition. It has important role in evaluating the patients' condition and the curative effect.
出处
《医学研究通讯》
2004年第1期52-53,共2页
Bulletin of Medical Research
