摘要
6例晚期肺癌病人经支气管动脉灌注(BAI)顺铂,另2例经肘静脉灌注顺铂。取血样后用极谱法测定顺铂的血药浓度,行药代动力学分析。结果表明顺铂两种方式给药,药代动力学均表现为二房室模型。经支气管动脉注药病人血液中游离铂的浓度高于经静脉注药病人血中的浓度,前者血中游离铂的消除相半衰期也长于后者。文章讨论了这种差异可能的原因及其临床意义。
Cisplatin was infused into bronchial artery (BAI) in six patients with advanced lung cancer and into median cubital vein in other two patients. The concentration of cisplatin in blood was determined by polarographic method for pharmacokinetic study of the agent. The blood drug--time curves of ofter infusing cisplatin by different route. were conformed to two-conpartment open model. The concentration of free cisplatin in plasma of patients after BAI was higher than that of patients after intravenous infusion, and the terminal half life period (t1/2β) is longer in patients by BAI than that in petients infused by vein.
出处
《现代诊断与治疗》
CAS
1992年第2期199-202,共4页
Modern Diagnosis and Treatment
关键词
顺铂
肺肿瘤
药代动力学
BAI
Cisplatin
Lung cancer
Bronchial artery infusion (BAI)
Pharmacokinetics
