摘要
目的 研究妇科恶性肿瘤患者血浆纤维蛋白溶解系统的改变。方法 采用定量酶联免疫吸附试验和发色底物法 ,对 5 7例妇科恶性肿瘤患者 (肿瘤组 )、30例非恶性肿瘤者 (对照组 )血浆中组织型纤溶酶原激活物 (t PA)、纤溶酶原激活物抑止物 (PAI 1)和D 二聚体 (D D)含量及t PA和PAI 1活性进行测定。结果 肿瘤组血浆t PA含量与活性较对照组明显升高 ,PAI 1活性明显下降 ,差异有显著性 (P <0 .0 1) ;D D含量较对照组明显升高 (P <0 .0 5 )。结论 血浆纤溶系统在妇科恶性肿瘤中有明显改变 ,这种改变可能与妇科恶性肿瘤的发展相关 。
Objective The alterations of the fibrinolysis system were studied by measuring the activities and concentrations of plasminogen activator(PA),plasminogen activator inhibitor(PAI) and D dimer.Methods The items were determined by the enzyme linked immunoassay and substrate luminescence in 57 patients with gynecologic malignancies and 30 non cancer female patients.Results The activity and concentration of t PA in gynecologic malignancies were significantly increased comparing with those of the control group ( P <0.01), D dimer concentration was higher in cancer patients than that in non cancer patients ( P <0.05). Whereas the activity and concentration of PAI in gynecologic malignancies were significantly decreased comparing to those of the control group ( P <0.01).Conclusion The plasma fibrinolysis system has significant changes in patients with gynecologic malignancies which may be related to the progression of cancerous process。It is important to study further more the relationship between the alterations of the fibrinolysis system and metastasis of gynecologic cancer.
出处
《上海医学》
CAS
CSCD
北大核心
2004年第1期47-48,共2页
Shanghai Medical Journal
