期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

瘦素在女性不孕症发病机制中的作用 被引量：3

Action of leptin on the pathogenesis of female infertility
暂未订购
导出
摘要 瘦素 (leptin)是近年发现的Ⅰ型细胞因子 ,参与调节体内的能量平衡、脂肪贮存等生理作用 ,并参与代谢、生殖、造血等功能。瘦素可能在脂肪组织和生殖系统间起关键性的桥梁作用 ,其过多或不足所致不孕均和一系列与营养状态相关的疾病有关 ,其在下丘脑 垂体 卵巢轴 (HPG) Leptin is type I cytokine detected recently.It takes part in physiological action such as energy balance, fat storage and process of metabolism,reproduction and hemopoiesis in vivo.Leptin may be an important role between adipose tissue and genital system.Lack or excessive of leptin is related to infertility in some diseases involving in nutritional status. Leptin takes part in female infertility pathogenesis in hypothalamus pituitary gland gonad axia and other respects.
作者 蒋立艳 成娅
机构地区 第三军医大学第二附属医院妇产科
出处 《医学研究生学报》 CAS 2003年第10期792-794,共3页 Journal of Medical Postgraduates
关键词 瘦素 女性不孕症 作用机制 Leptin Female infertility Action mechanism
分类号 R711.6 [医药卫生—妇产科学]
  • 相关文献

参考文献18

  • 1Zhang Y,Proenca R,Maffei M et al.Positional cloning of the mouse obese gene and its human homologue[J].Nature,1994,372(6505):425- 432.
  • 2Isse N,Ogawa Y,Tamura N et al.Structural organizaiton and chromosomal assignment of the human obese gene[J].J Biol Chem,1995,270(46):27728- 27733.
  • 3Tartaglia L,Dembski M,Weng X.Identification and expression cloning of a leptin receptor,Ob-R[J].Cell,1995,83(7):1266-1271.
  • 4Juan CS,Liliana M.Leptin in obstetrics and gynecology:a review[J].Obstet Gynecol Surv,2001,56(4):225-230.
  • 5Schubring,C, Blum WF,Kratzsh J et al.Leptin,the ob gene product, in female health and disease[J].Eur J Obstet Gynecol Reprod Biol,2000,88(2):121-127.
  • 6Moschos C, Chan JL,Mantzoros CS et al.Leptin and reproduction:a review[J].Fertil Steril,2002,77(3):433-444.
  • 7Muhittin HT.Serum leptin levels in patients with polycystic ovary syndrome[J].Fertil Steril,2002,77(5):932-635.
  • 8Fedorcsak P,Storing R,Dale PO et al.Leptin and leptin binding activity in the preovulatory follicle of polycystic ovary syndrome patients[J].Scand J Clin Lab Invest,2000,60(8):649-655.
  • 9Gogacz M, Polak G, Jakowichi J et al.Peritoneal fluid leptin concentration in infertile patients[J].J Reprod Immunol, 2001,51(2):159-165.
  • 10Michael Rosenbaum, Rudolph L.Leibel leptin:a molecule integrating somatic energy stores[J].Energy Exp Fertil TEM,1998,9(3):117-124.

同被引文献18

  • 1蔡滢,李晓东,王飞,田楠,田德润.食源性肥胖大鼠下丘脑弓状核NPY表达上调[J].天津医科大学学报,2005,11(1):1-4. 被引量：11
  • 2Ihle .IN. STATS : signal transduces and activatous of transcription [ J ]. Cell, 1996,84(3) :331.
  • 3Fedorcsak P, Storing R, Dale PO, et al. Leptin and leptin binding activity in the preovulatory follicle of polycystic ovary syndrome patients [J]. Scand J Clin Lab Invest,2000,60(8) :649.
  • 4Spicer LJ, Francisco CC. The adipose obese gene product, leptin, evidengce of a inhibitory in ovarian function[J]. Endocrinology, 1997, 128 (7) :3374.
  • 5Schneidera J E,Zhoua D, Bluma RM, et al. Leptin and metabolic control of reproduction [J]. Schneidera, Horm Behav,2000,37 (4) :306.
  • 6Barroso G, Barrinuevo M, Rao P, et al. Vascular endothelisl growth factor, nitric odd, and leptin follicular fluid levels correlate negatively with embryo quality in IVF patients[J]. Fertil Steril, 1999,72:1024.
  • 7Brannian JD, Schmidt SM, Kreger DO, et al. Baseline non-fasting serum leptin concentration to body mass index ratio is predictive of IVF outcomes [J]. Hum Reprod,2001,16(9) : 1819.
  • 8Telli MH, Yildirim M, Noyan V. Serum leptin levels in patients with poly-cystic ovary sydrom[J]. Fertil Steril,2002,77(5):932.
  • 9Daniel Castracane V, Ginger R. Kraemer et al. Interrelationships of serum estradiol, estrone, and estrone sulfate, adiposity, biochemical bone markers, and leptin inpostmenopausal women [ J] . Maturitas, 2006, 53:217-25.
  • 10Alfer J, Muller - Schottle F, Classen - Link Iet al. The endometrium as a novel target for leptin: differences in fertility and subfertility [ J] . Mol Hum Reprod, 2000, 6:595-601.

引证文献3

二级引证文献6

医学研究生学报
2003年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部