摘要
目的 :探讨p16和细胞周期素依赖性激酶 4 (cyclindependentkinase 4 ,CDK4 )在子宫内膜腺癌中的表达及其临床意义。方法 :采用免疫组化SP法检测 32例子宫内膜腺癌中p16和CDK4蛋白的表达。结果 :32例子宫内膜腺癌中p16蛋白表达阳性率为 4 3.8% ,p16阳性表达与子宫内膜腺癌的组织学分级、肌层浸润深度和淋巴结转移呈负相关 (P <0 .0 5 ) ,但和临床分期无关 (P >0 .0 5 )。CDK4在子宫内膜腺癌中的阳性表达率为 68.8%(2 2 /32 ) ,CDK4阳性表达与子宫内膜腺癌的浸润深度和淋巴结转移呈正相关 (P<0 .0 5 ) ,与组织学分级和临床分期无关 (P >0 .0 5 )。p16和CDK4的表达呈负相关 (P <0 .0 5 )。结论
Objective:To study the expressions of p16 and CDK4 proteins in endometrial adenocarcinoma and the clinical pathological significance.Methods:Expressions of p16 and CDK4 proteins were detected by immunohistochemical technique in 32 cases of endometrial adenocarcinoma.Results:The positive expression rate of p16 protein in endometrial adenocarcinoma was 43.8%(14/32).The positive rate of p16 in endometrial adenocarcinoma was related negatively to pathological grade,myometrial invasion and lymph node metastasis(P<0.05), but unrelated to clinical stage(P>0.05).The positive expression rate of CDK4 was 68.8%(22/32).CDK4 expression was significantly associated with myometrial invasion and lymph node metastasis(P<0.05), but unrelated to pathological grade and clinical stage (P>0.05). There was negative correlation between p16 and CDK4(P<0.05).Conclusions:p16 and CDK4 as cell cycle regulatory factors may be involved in carcinogenesis and development of endometrial adenocarcinoma.
出处
《现代妇产科进展》
CSCD
2003年第3期185-187,共3页
Progress in Obstetrics and Gynecology
基金
芜湖市科委重点基金资助项目 ( 2 0 0 1 13 0 )
