摘要
目的 :检验一条合成肽在中和内毒素活性方面的作用。方法 :在内毒素刺激人THP - 1细胞分泌细胞因子TNF -α模型上 ,观察合成肽、多黏菌素B、合成肽和多黏菌素B对内毒素激活THP - 1细胞的影响。结果 :多黏菌素B抑制内毒素激活THP - 1细胞 ,合成肽增强多黏菌素B的抑制作用。结论
AIM:To verify the role of a synthetic peptide in neutralizing endotoxins.METHODS:By model of LPS-induced TNF-α secretion in human THP-1 cells, the affects of anti-endotoxin capability of the peptide, polymyxin B, and the peptide plus polymyxin B were examined.RESULTS:Polymyxin B suppressed LPS-induced TNF-α secretion in human THP-1 cells. The peptide enhanced the capability of polymyxin B to suppress TNF-α secretion.CONCLUSION:The peptide could amplify the endotoxin-neutralizing capability of polymyxin B.
出处
《牙体牙髓牙周病学杂志》
CAS
2003年第6期314-317,共4页
Chinese Journal of Conservative Dentistry
关键词
内毒素
多黏菌素B
感染免疫
endotoxins
polymyxin B
infectious immunity
