摘要
目的 探讨Wilson病 (WD)患者是否出现选择性厌恶情绪认知障碍 ,以进一步验证基底节参与情绪加工的假说。方法 测试 32例WD患者 (WD组 )和 2 0名健康人 (对照组 )对 30张含有 6种基本情绪 (喜、惊、怕、悲、厌和怒 )面孔照片的辨认能力。结果 与对照组比较 ,WD组对厌 [(9.1± 4 .7)分 ,P <0 .0 0 1 ) ] ,怒和怕 [(1 4 .9± 4 .3)分 ;(1 2 .8± 3 .6)分 ,P均 <0 .0 5]情绪面孔的辨别有障碍 ,而相对于怕和怒 ,厌的认知障碍更为明显。
Objective The selective deficit of recognition of disgust expression in Huntington’s disease (HD) and HD gene carrier strongly suggested the possibility that basal ganglia is involved in disgust processing. To further tested this hypothesis, we test the perception of emotional expressions in patients with symptomatic Wilson’s disease (WD), another basal ganglia disease resulted from abnormal copper metabo lism. Methods We developed a six basic emotional morphed face continuum (30 morphed emotional faces across happy surprise fear sad disgust anger happy). Participants were required to label each of these morphs in 5 trails to measure the ability of different emotion processing. The performances of 32 cases of WD were compared with 20 age and education matched normal controls. Results On the group level, although significantly impaired in fear, disgust and anger (correct identification scores: 12.8±3.6;9.1±4.7;14.9±4.3, P <0.05; P <0.001; P <0.05 respectively compared with normal controls), WD manifested deferentially severe deficit in disgust processing (score in disgust significantly worse than that of fear and anger P < 0.001). Conclusion The differentially severe deficit of disgust in WD supported that basal ganglia might play an important role on disgust processing. Combined with selective deficit of fear processing in cases with bilateral amygdala or bilateral cingulate gyrus lesions, the result here represented the double dissociation, which in turn suggested that certain different basic emotion could have distinct neural substrates.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2003年第2期90-93,共4页
Chinese Journal of Neurology
基金
安徽省自然科学基金资助项目( 0 10 4 36 0 2)
安徽省优秀青年科技基金资助项目([2 0 0 2 ] 0 2 )
