摘要
目的 :研究核转录因子 κB(nucleartranscriptionfactor κB ,NF κB)在原发性肝细胞癌、肝硬化组织和正常肝组织中的表达及与临床的关系 .方法 :应用免疫组织化学方法对 6 3例原发性肝细胞癌、2 0例肝硬化、1 0例正常肝组织石蜡包埋标本进行NF κB半定量检测 .结果 :6 3例原发性肝细胞癌中有 5 2例NF κB阳性表达 (82 .5 % ) ,而肝硬化中NF κB阳性表达率仅为 2 5 % ,二者存在显著性差异 (P <0 .0 1 ) ;低分化癌的NF κB阳性率明显高于高分化癌 (P <0 .0 1 ) .NF κB阳性表达率在甲胎蛋白 (alphafetoprotein ,AFP)高表达肝癌组高于AFP低表达组 (P <0 .0 1 ) .NF κB阳性表达率在有淋巴结转移肝癌组织高于无淋巴结转移组 (P <0 .0 1 ) .NF κB高表达 ,患者预后不佳 .结论 :NF κB在原发性肝细胞癌组织中表达增强 ,且与癌组织的分化程度、有无淋巴结转移、患者AFP水平呈正相关 ,NF
AIM: To study the expression of NF κB in primary hepatocellular carcinoma and its clinical implications. METHODS: Ninety three paraffin embedded samples were studied with immunohistochemical techniques (SABC method), 63 of which were from primary hepatocellular carcinoma tissues, 20 from sclerotic liver tissues and 10 from normal liver tissues. RESULTS: Expression of NF κB both in 82.5% samples of primary hepatocellular carcinoma and 25.0% samples of sclerotic liver tissues was more obvious than that in the normal liver tissues. The positivity rate of NF κB was higher in poorly differentiated carcinoma group than that in well differentiated group ( P <0.01). The positivity rate of NF κB was more obvious in high level AFP group than that in low level group ( P <0.01). The positivity rate of NF κB was more obvious in metastatic carcinoma group than that in non metastatic group ( P <0.01). The hepatocellular carcinoma patients with an overexpression of NF κB had a poor prognosis. CONCLUSION: Overexpression of NF κB may be correlated with tumor differentiation, AFP level, metastasis and prognosis of primary hepatocellular carcinoma.
出处
《第四军医大学学报》
北大核心
2003年第24期2269-2271,共3页
Journal of the Fourth Military Medical University
关键词
癌
肝细胞
NF—κB
免疫组织化学
carcinoma, hepatocellular
NF kappa B
immunohistochemistry
