摘要
目的 :观察左旋卡尼汀与红细胞生成素 (EPO)合用对维持性血液透析 (HD)患者透析耐受性的影响。方法 :选择HD患者 2 6例 ,随机分为A、B两组 ,每次透析结束后A组静脉注射左旋卡尼汀 1g。B组除左旋卡尼汀外 ,给予EPO12 0u/kg·w ,皮下注射。 10周分别观察治疗前后临床症状及血液、生化指标的变化。结果 :两组体力、精神状态、食欲、透析中肌痉挛、低血压等症状都有改善 ,B组改善更明显。与A组比 ,B组的干体重及血浆蛋白升高显著 (P <0 .0 5 ) ,血红蛋白 ,血球压积变化差异更显著 (P <0 .0 1)。结论 :两药合用可提高HD患者的透析耐受性。
Objective: To investigate the influence on maintenance hemodialysis patients' dialysis tolerance of integrating L-carnitine with erythropoietin(EPO). Method: Twenty-six maintenance hemodialysis patients were divided into two groups: A and B .in group A(n=13),1g of L-carnitine was infused to the patients at the and end of each hemodialysis treatment. In group B(n=13) apart from L-carnitine, Epo (120u/kg,each week)was infused to the patients for ten weeks. The improvement of clinical symptom, blood and biochemistry target were observed separately.Result: Both of them were improved in physical and mental status, appetite, intra-dialytic hypotension and cramps, the group B was improved significantly. Net weight, hemoglobin, hemotocrit and serum albumin were rising, and the group B was rising significantly. Conclusion: To integrate L-carnitine with Epo can improve maintenance hemodialysis patients' dialysis tolerance.
出处
《河北医学》
CAS
2003年第12期1063-1065,共3页
Hebei Medicine
