摘要
目的 探讨血管紧张素转换酶抑制剂雷米普利减少心肌梗死后患者心肌缺血及缺血事件的作用。方法 对 4 0例雷米普利组 (治疗组 )和 38例一般治疗组 (对照组 )于出院前 ,出院后 0 .5、1.0年行 2 4小时动态心电图心肌缺血总负荷检测 (TIB) ,并观察缺血相关事件。结果 治疗组TIB在出院后 6个月低于对照组 ,但无统计学差异 (P >0 .0 5 )。出院后 1年 ,治疗组TIB显著低于对照组 (P <0 .0 5 ) ,并且治疗组缺血相关事件亦明显少于对照组 (P <0 .0 5 )。结论 雷米普利对心肌梗死后患者具有长期的抗心肌缺血和减少缺血事件的作用。
Objective To study the effect of ramipril(angiotensin-converting enzyme inhibitor) on myocardial ischemia and related events following myocardial infarction(MI). Methods 40 cases of ramipril group and 38 cases of control group underwent total ischemic burden(TIB) testing of 24 ambulatory electrocardiogram recording before and 6 and 12 months after hospital discharge and ischemia-related events were observed. Results TIB in ramipril group was lower than in control group after 6 months,with no statistical difference(P>0.05). One year after hospital discharge TIB in ramipril group was significantly lower than in control group(P<0.05) while fewer ischemia-related events occurred in ramipril group than in control group(P<0.05). Conclusion Ramipril has long-term anti-ischemic effect and may reduce the incidence of ischemia-related events after MI.
出处
《中国综合临床》
北大核心
2004年第1期17-18,共2页
Clinical Medicine of China
关键词
心肌梗死
雷米普利
心肌缺血
Myocardial infarction
Ramipril
Myocardial ischemia
