摘要
目的 :研究兔关节内注射放射性核素1 53 钐 -柠檬酸 -羟基磷灰石 (1 53 Sm -citrate -HA)制剂的生物学分布及病理学变化。方法 :将 30只新西兰大白兔分为 4组 ,其中 2 4只制作成抗原诱导关节炎 (antigeninducedarthritis,AIA)模型 (AIA兔 )。A组为正常兔 6只 ,B组AIA兔 1 2只 ,2组膝关节腔内注射1 53 Sm -citrate -HA 3.7× 1 0 7Bq后分别于第 3d、第 6d显像 ,用SPECT获得放射性计数并计算核素在关节内滞留率及生物学分布、漏出率。C、D组均为AIA兔 6只 ,C组不做任何治疗 ,D组关节腔内注射1 53 Sm -citrate-HA 3.7× 1 0 7Bq ,2组观察 30d后取滑膜、软骨行病理学观察。结果 :A、B组关节腔内核素的滞留率分别为 (97.7± 1 .2 ) % (3d)、(93.5± 0 .9) % (6d)和 (98.4±1 .4 ) % (3d)、(95 .1± 0 .5 ) % (6d)。关节外漏出率分别为 0 .1 7% (3d)、0 .31 % (6d)和 0 .0 7% (3d)、0 .0 9% (6d)。病理学观察 :D组较C组滑膜炎症明显好转 ,关节软骨未发现损害。结论 :1 53 Sm -citrate-HA漏出率低 ,关节内分布均匀且滞留率高 ,疗效肯定 。
Aim: To study the biological distribution and pathological changes of intra-articular injected 153 Sm-citrate-hydroxyaptite in antigen-induced arthritis rabbits. Methods: Thirty New Zealand rabbits were allocated into four groups. Group A ( n =6) was normal and Group B ( n =12) was AIA (antigen induced arthritis) rabbits. Both groups were injected 153 Sm-citrate-HA 3.7×10 7 Bq in knee joint and were scanned by single ploton emission computed tomography (SPECT) at 3rd and 6th day after injection, then the residual rates in knee joint and bio-distribution were calculated. Group C and D were both AIA rabbits, group C ( n =6) were not treated and group D ( n =6) were injected 153 Sm-citrate-HA 3.7×10 7 Bq in the ill knee joint, then histopathologic changes were observed 30 days later. Results: The intra-articular residual rates were (97.7±1.2)% (3 days), (93.5±0.9)% (6 days) for Group A and (98.4±1.4)% (3 days), (95.1±0.5)% (6 days) for Group B, and the total cumulative extra-articular leakage were 0.17% (3 days), 0.31 % (6 days) for Group A, and 0.07% (3 days) and 0.09% (6 days) for Group B. Histopathologic changes of Group D has been controlled compared with Group C. Conclusion: 153 Sm-citrate-HA radiation therapy is effective and safe with low leakage and high intra-articular residual rates of radioisotope.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2004年第1期74-77,共4页
Journal of Zhengzhou University(Medical Sciences)
