摘要
目的 :探讨氟伐他汀对老年原发性高胆固醇血症 (PHC)的疗效、安全性及耐受性。方法 :采用随机双盲平行对照法 ,将 82例老年PHC病人分成氟伐他汀组 (试验组 ) 42例和安慰剂组 (对照组 ) 40例 ,氟伐他汀 2 0mg/d～ 40mg/d ,治疗 12周后观察疗效和安全性。结果 :用药 12周后血清总胆固醇(TC )、低密度脂蛋白胆固醇(LDL -C)、三酰甘油 (TG)结果升高 ,两组较治疗前均值下降率比较有统计学意义 (P <0 .0 5～ 0 .0 1) ,两组副反应发生率分别为 7.5 %和5 .1% (P >0 .0 5 ) ,主要表现为胃肠道症状 ,均可耐受。结论 :服用氟伐他汀 2 0mg/d～ 40mg/d治疗老年PHC ,能明显降低TC、TG、LDL -C ,升高HDL -C ,且安全性好 ,易于耐受。
Objective:To investigate the efficacy,security ,and endurance of fluvastatin in the old patients with primary hypercholesterolemia (PHC).Methods:The 82 cases of old patients with PHC were divided into two groups by random, double-blind,and parallel-controlled ways. The fluvastatin group had 42 cases and the placebo group had 40 cases. The efficacy and security of fluvastatin (20 mg/d～40 mg/d) were observed 12 weeks later. Results:The serum value of two group had statistics difference in total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triglyceride (TG),and high density lipoprotein cholesterol (HDL-C) 12 weeks later (P<0.05～0.01).The side reactions rate of two group were 7.5% and 5.1% respectively (P>0.05).It was gastrointestinal disorder mainly.But it could be endurable. Conclusion:The serum value of TC,TG,and LDL-C could be decreased and HDL-C could be increased by Fluvastatin (20 mg/d～40 mg/d) significantly.It was safe and endurable.
出处
《中西医结合心脑血管病杂志》
2003年第11期671-672,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
老年
高胆固醇血症
氟伐他汀
药物治疗
Hypercholesterolemia
Primary
Total cholesterol (TC)
Fluvastatin
