摘要
目的 :评价咪唑安定与吗啡联合用于术后硬膜外镇痛的有效性。方法 :60例择期妇科手术病人根据所用术后镇痛药物的不同随机分为 3组 ,每组 2 0例 , 组 :咪唑安定 3mg+吗啡 2 mg; 组 :咪唑安定3mg; 组 :吗啡 2 mg。测定术后不同时期视觉模拟评分 ( VAS)及血清皮质醇、血管紧张素 ( Ang )和白细胞介素 - 6( IL- 6)的变化。结果 :与同时期 组比较 , 组术后 4～ 2 4 h、 组术后 8～ 2 4 h VAS值较 组高( P<0 .0 1或 P<0 .0 5 )。术后 2 4 h 、 两组皮质醇浓度明显高于 组 ( P<0 .0 5 )。术后 2 4 h和 48h 、 两组 IL- 6级 Ang 浓度均高于 组 ( P<0 .0 5或 P<0 .0 1 )。结论
Objective:To estimate the efficacy of epidural midazolam combined with morphine for postoperative analgesia.Methods:Sixty patients,ASA Ⅰ Ⅱ,scheduled for gynecologic surgery,were randomly divided into three groups according to the analgesics.Group Ⅰ received midazolam 3mg+morphine 2mg,group Ⅱ midazolam 3mg,and group Ⅲ morphine 2mg. VAS,serum cortisol,angiotension Ⅱ(AngⅡ) and interleukin 6(IL 6) were measured at different times postoperatively.Results:Compared with that in group Ⅰ at the same time,VAS was high at 4,8,12 and 24 h in group Ⅱ and at 8,12 and 24 in group Ⅲ ( P <0 01 or P <0 05).The levels of serum cortisol were higher at 24h in both group Ⅱ and group Ⅲ( P <0 05).The levels of AngⅡ and IL 6 were higher at 24 h and 48 h in both group Ⅱ and group Ⅲ( P <0 05 or P <0 01).Conclusion:Epidural midazolam combined with morphine is superior to midazolam or morphine alone for postoperative analgesia.
出处
《滨州医学院学报》
2004年第1期22-24,共3页
Journal of Binzhou Medical University
