摘要
目的 :研究心房颤动患者是否存在血小板激活和内皮功能损伤 ,探讨其与血栓栓塞并发症的关系。方法 :根据经食管超声心动图有无检出血栓及有无栓塞并发症将 45例心房颤动患者分为两组 :血栓阳性组 ( 9例 )和血栓阴性组 ( 3 6例 ) ,分别用ELISA法测定其血浆可溶性P -选择素、vWF、D -二聚体水平 ,用全自动生化分析仪测定MPV ,对其结果进行对照分析。结果 :慢性心房颤动患者血浆可溶性P -选择素、vWF、MPV、D -二聚体水平显著升高 (P <0 .0 5 ) ,其中血浆可溶性P -选择素、D -二聚体水平在血栓阳性组和血栓阴性组中亦有显著差异 (P <0 .0 5 )。且可溶性P -选择素与D -二聚体水平呈正相关 (rs=0 .3 2 0 ,P <0 .0 5 )。结论 :心房颤动患者存在有血小板激活及内皮功能损伤 ,且这些异常改变与其血栓形成及栓塞并发症有一定关系。
Objective To investigate platelet activation and endothelial damage in patients with atrial fibrillation,and the relationship between platelet activation and endothelial damage with embolism complication.Methods Forty-five patients with chronic atrial fibrillation were divided into 2 groups based on TEE and embolism complication:thrombus group and non-thrombus group.The plasma soluble P-selectin,von Willbrand factor and D-dimer were assayed with ELISA.Mean platelet volume was measured by automatic hematologic analyzer.Results Compared with the normal sinus rhythm group,the plasma level of soluble P-selectin,vWF and D-dimer were significantly higher(P<0.05) in patients with atrial fibrillation,and there were also significant differences between thrombus group and non-thrombus group of the soluble P-selectin and D-dimer(P<0.05). Soluble P-selectin was positive correlated with D-dimer(r s= 0.320, P<0.05).Conclusion Patients with atrial fibrillation show evidence of platelet activation and endothelial damage,which may correlate with the atrial thrombus and embolism complication.
出处
《实用诊断与治疗杂志》
2004年第1期8-9,23,共3页
Journal of Practical Diagnosis and Therapy
关键词
心房颤动
血小板激活
内皮功能损伤
血栓栓塞
Atrial fibrillation
platelet activation
endothelial damage
embolism complication
