摘要
目的探讨女性更年期痤疮患者血清性激素水平的变化,临床特征及治疗方法。方法对66例患者的临床特征及治疗进行了观察;测定其中35例患者的血清睾酮和雌二醇水平。结果患者睾酮、雌二醇与正常人对照组相比较差异无显著性,但睾酮/雌二醇显著高于正常人对照组(P<0.05)。63.6%的患者在更年期发病。皮损以上唇及颏部最多,其次为颊部、额部,多呈散在分布,以粉刺及炎性丘疹或丘脓疱疹为主,少数有炎性结节。多为轻至中度痤疮。78.8%的患者一般治疗即可治愈,其余患者用性激素治愈。结论更年期因卵巢功能衰退,雌激素分泌减少,雌雄激素比例失衡,肾上腺源性雄激素相对过甚而导致痤疮。更年期痤疮多为轻至中度,皮损以粉刺、炎性丘疹或丘脓疱疹为主,以上唇及颏部最多。绝大多数患者一般治疗即可治愈。
Objective To investigate serum levels of sex hormones,clinical features and therapeutic regimen in women with climacteric acne.Methods The characteristics of skin lesions and therapeutic effect were observed in66female patients with climacteric acne.The serum levels of testosterone,and estradiol were measured with radioimmunoassay in35patients.Results No significant difference was found in the serum levels of testosterone and estradiol between the patients and normal controls(P>0.05),but the ratio of testosterone/estradiol was significantly higher in patients than that of the controls(P <0.05).The clinical features were as follows:(1)The lesions started in climacteric period in63.6%cases.(2)Most lesions scat-tered around mouth and chin,then on the cheek and frontal part.(3)The acne was mild to moderate in severi-ty,consisting mainly of comedones and inflammatory lesions(papules and papulopustules).(4)78.8%climac-teric acne patients were cured with ordinary therapy,the others with sex hormone therapy.Conclusions The ratio of estrogen and androgen is unbalanced,and the level of adrenal androgens is relatively increased in cli-macteric acne patients.Most cases are mild to moderate in severity,most patients can be cured with ordinary therapy.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2003年第6期338-339,共2页
Chinese Journal of Dermatology
