雷莫司琼预防化疗药物所致胃肠道反应的临床观察被引量：9

Effects of Nasea on prevention of gastrointestinal side effects caused by chemotherapeutic drugs

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摘要目的　观察盐酸雷莫司琼 (奈西雅 )注射剂治疗化疗药物所引起的胃肠反应和毒副作用 ,并与恩丹西酮 (欧贝 )比较 ,观察两药的疗效和安全性。方法　采用前瞻性随机对照研究的方法 ,将入院患者随机分为奈西雅组 (A组 )和欧贝组 (B组 ) ,分别观察化疗后 3d内食欲不振、恶心、呕吐和其他毒副反应。结果　收治的 89例患者 ,可评价疗效 85例 ,在化疗后 0～ 6h、6～ 12h、2 4～ 4 8h、4 8～ 72h奈西雅对食欲不振、恶心、呕吐的完全控制率和有效率与欧贝相比较略有优势 ,但差异无显著意义。而在 12～ 2 4h奈西雅组在食欲不振、恶心、呕吐方面的完全控制率 (分别为 4 1 9%、32 6 %、5 3 5 % )和有效率 (分别为 76 7%、75 1%、83 7% )均明显优于对照组 (完全控制率分别为 31 0 %、2 6 2 %、4 2 9% ;有效率分别为 4 0 5 %、4 2 9%、5 4 8% ) ,结果有显著的差异 (P <0 0 5 )。说明奈西雅的作用时间较欧贝长 ,其有效率奈西雅组高于后者。奈西雅不良反应较轻 ,主要为头痛、口干、便秘等 ,与欧贝比价差异无显著意义。结论　奈西雅能有效地治疗化疗所致的胃肠道反应 ;其疗效与欧贝相似 ,但作用持续时间较欧贝长 ,毒副反应轻 ,是新一代 5 HT3 受体拮抗剂。 Objective To investigate the effects of Nasea on prevention of gastrointestinal side effects caused by chemotherapeutic drugs. Methods Eighty-five in-patients with cancer undergoing chemotherapy were randomly divided into 2 groups: Nasea group (group A, n =43, Nasea, ramosetron hydrochloride was injected intravenously 30 minutes before chemotherapy) and ondansetron group (group B, n =42, ondamsetron was injected intravenously 30 minutes before chemotherapy). The side effects of chemotherapy, including nausea, vomiting, anorexia, etc, were observed during the 3 days after chemotherapy. Results The complete effective rate and effective rate of prevention of nausea, vomiting, and anorexia during the periods 0～6 hours, 6～12 hours, 24～48 hours, and 48～62 hours after chemotherapy were similar in these 2 groups. However, these rates during the period 12～24 hours after chemotherapy were significantly higher in group A than in group B (all P <0.05). The side effects of these 2 drugs included carebarja, headache, fatigue, etc, all being mild and not significantly different between these 2 groups. Conclusion Effectively preventing the gastrointestinal side effects caused by chemotherapeutic drugs with an efficacy similar to that of ondansetron and seemingly lasting longer, Nasea is a promising drug.

作者谢晓冬郑振东刘大为刘永叶单学健

机构地区沈阳军区总医院肿瘤科

出处《中华医学杂志》 CAS CSCD 北大核心 2003年第13期1180-1182,共3页 National Medical Journal of China

关键词雷莫司琼预防化疗药物胃肠道反应临床观察 Antiemetics Ramosetron hydrochloride Ondansetron hydrochloride Gastrointestinal motility

分类号 R730.5 [医药卫生—肿瘤]

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