摘要
目的:探讨Ⅲ期卵巢上皮癌术前CA125水平与手术彻底性的关系。方法:回顾手术治疗的86例Ⅲ期卵巢上皮癌患者术前CA125水平以及相应的手术彻底性临床资料,应用受试者工作特征(ROC)曲线探讨术前CA125水平与手术彻底性的关系,并确定作为预测手术彻底性诊断界点的CA125水平。结果:86例患者中46例(53.5%)完成了满意的肿瘤减灭术(残留肿瘤最大径≤2cm);随着CA125水平增加肿瘤减灭术满意性下降;CA125预测手术彻底性的诊断界点是750μ/ml,术前CA125<750μ/ml的患者中34例(63.4%)完成了满意的减灭术,而术前CA125>750μ/ml的患者中12例(35.3%)完成了满意的减灭术;以超过750μ/ml无法完成满意的减灭术为阳性,敏感性64.7%,特异性65.4%,阳性预测值55.0%,阴性预测值73.9%。结论:Ⅲ期卵巢上皮癌患者术前CA125超过750μ/ml者,须充分评估手术可行性。
Objective:To assess the predictive value of preoperative serum CA125to opti-mal tumor cytoreduction in stageⅢepithelial ovarian carcinoma.Methods :We retrospectively re-view the preoperative serum CA125values and operation records of86consecutive patients with stageⅢepithelial ovarian carcinoma and determined the CA125level with the maximal prognos-tic power in predicting optimal versus suboptimal cytoreduction by means of receiver operating characteristic curve(ROC curve).Results:The optimal cytoreduction(diameter of largest residual tumor nodule≤2cm)was obtained in46patients(53.3%).The probability of performing optimal cytoreduction decreased with increasing CA125levels.A preoperative CA125level of750u/ml was identified as the value with the most predictive power.Optimal cytoreduction was achieved in34(63.4%)cases with CA125less than750u/ml compared to12(35.3%)cases with CA125greater than750u/ml.Defining suboptimal cytoreduction cases with CA125greater than750u/ml as positive,the sensitivity,specificity,positive predictive value and negative predictive value were respectively64.7%,65.4%,55%and73.9%.Conclusion:Those patients of stageⅢepithelial o-varian carcinoma with preoperative CA125greater than750u/ml should be fully assessed the probability of optimal cytoreduction preoperatively.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2003年第10期718-720,共3页
Chinese Journal of Clinical Oncology
