摘要
背景与目的:探讨海带、裙带菜、条斑紫菜、坛紫菜4种常见海藻水溶性提取液(简称海藻水提液)的体外免疫调节活性。材料与方法:采用3H-TdR掺入法分析了海藻水提液对小鼠脾淋巴细胞增殖作用的影响;采用生物学方法测定了小鼠单核细胞产生肿瘤坏死因子(TNF-α)的作用。结果:4种海藻的水溶性提取液对小鼠脾细胞的增殖均有不同程度的促进作用,但不同海藻的促进作用存在着差别;海藻水提液在体外能激活小鼠单核细胞并产生大量TNF-α,促进其吞噬或杀伤肿瘤细胞。结论:海带、裙带菜、条斑紫菜和坛紫菜的水提液对小鼠淋巴细胞的增殖均有不同程度的促进作用,均可显著刺激小鼠单核细胞产生TNF-α。
BACKGROUND & AIM: To investigate biological characteristics of four seaweeds extracts through im-munoregulating test. MATERIAL AND METHODS: Effects of the four seaweed's extracts on proliferation of spleen cells of mice were analyzed by 3H-TdR in corporation methods. Effects of the four marine algae on stimulating tumor necrosis factor - α(TNF- α) secretion from mice monocytes were examined by a biology method. RESULTS: All of the four seaweeds extracts had effects of promoting proliferation of spleen cells of mice, but the promotive effect was different among the four seaweeds. In vitro test, four seaweeds extracts could activate mice monocytes to produce more TNF - α. CONCLUSION: The present study indicates that four seaweeds have the effects of promoting the proliferation of mice spleen cells, and can induce mice monocytes to produce TNF - α.
出处
《癌变·畸变·突变》
CAS
CSCD
2004年第1期36-38,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
河北省中医药管理局资助课题(No.0353)
关键词
海藻
淋巴细胞增殖
单核细胞
肿瘤坏死因子
seaweed
proliferation of lymphocytes
monocyte
tumor necrosis factor
