摘要
目的 :探讨核因子 κB、C myc和ICAM 1的活性表达在结直肠癌发生 ,转移中的作用及其临床意义。方法 :采用免疫组化S P法测定 5 0例结直肠癌、16例结直肠腺瘤、9例结直肠腺瘤癌变和 8例正常结肠组织中NF κBp6 5、C myc和ICAM 1的表达。 结果 :结直肠癌、结直肠腺瘤癌变组织中NF κBp6 5、C myc的表达明显高于结直肠腺瘤 (P <0 .0 1) ,C myc在正常结肠组织中无表达 ;NF κBp6 5、C myc在结直肠癌中表达成显著正相关 (r =0 .35 ;P <0 .0 1) ;NF κBp6 5和ICAM 1在有转移的结直肠癌组织中的表达比无转移的结直肠癌显著增加 (P <0 .0 1) ;且两者与结直肠癌的转移具有显著正相关性 (r =0 .2 9;P <0 .0 1)。结论 :NF κB通过对C myc、ICAM 1的转录调控在结直肠癌发生、转移过程中发挥重要作用 ,可能将成为结直肠癌治疗的一个新靶点。
Objective:To explore the expressions of the nuclear factor-κB(NF-κB),C- myc and ICAM-1 in human colon and rectal cancer and the relationship between NF-κB and the occurrence,the metastasis of human colon and rectal cancer.The clinical significance was analyzed.Methods:Fifty human colon and rectal cancer cases ,16 colon and rectal adenomas,9 carcinomatous change of colon and rectal adenoma and 8 normal colon were studied,the expressions of NF-κ Bp65,C- myc and ICAM-1 in them were examined by immunohistochemical method.Results:NF-κBp65,C- myc were strongly expressed in the colon and rectal cancer and carcinomatous change of colon and rectal adenomas than those in colon and retal adenoma;C- myc could not express in normal colon;NF-κ Bp65 and C- myc were significantly positive correlation with colon and rectal cancer;NF-κBp65,ICAM-1 were strongly expressed in the colon and rectal cancer which had metastasis than those had no metastasis,and they had striking positive correlation with colon and rectal cancer which had metastasis.ConclusionTo control the transcription of C- myc and ICAM-1,NF-κB plays an important action in the occurrence and metastasis of colon and rectal cancer.It will become a new target of treatment of colon and rectal cancer.
出处
《中国现代普通外科进展》
CAS
2003年第4期224-227,共4页
Chinese Journal of Current Advances in General Surgery
