摘要
目的 比较射频消融 (RFA)、肝动脉栓塞化疗 (TAE)、选择性门静脉栓塞 (SPVE)及TAE联合SPVE治疗兔肝VX2 肿瘤的疗效。方法 采用移植的方法复制兔肝VX2 肿瘤并采用RFA、TAE、SPVE及TAE联合SPVE进行治疗 ,根据治疗方法的不同将实验动物分为RFA组、TAE组、SPVE组及TAE +SPVE组。结果 ①ALT在TAE +SPVE组第 1天时升高的幅度最大 ,4～ 7d内恢复较慢 ,RFA组升高幅度最小 ,恢复最快 ;SPVE组在第 1、4、7天时的ALT均明显低于TAE组及SPVE +TAE组。②SPVE、TAE及TAE +SPVE组治疗后 2周时CT均表现为肿瘤病灶内有碘油沉积 ,大体观察示病灶质地变硬 ,活检示TAE及TAE +SPVE组坏死范围较大 ,但均为不完全坏死。③治疗后 2周RFA组病灶完全坏死率明显高于SPVE及TAE组 ,RFA组肺转移率明显低于TAE组 ;RFA组 3个月生存率为 5 0 % ,其余 3组动物均在 2个月内逐渐死亡 ;RFA组生存时间比其它 3组均明显延长。结论 SPVE、TAE或二者联合应用对兔肝VX2 肿瘤的血管栓塞效果明显 ,但均不能使肿瘤病灶完全坏死 ,且对肝功能的损害较大 ;与血管栓塞疗法相比 ,RFA治疗兔肝VX2 肿瘤具有疗效好 。
Objective To compare the effect of radio frequency ablation (RFA ), transcatheter artery embolization(TAE), selective portal vein embolization(SPVE) and TAE combined with SPVE in the treatment of hepatic VX 2 tumors. Methods The VX 2 hepatoma model was replicated with the method of implantation in rabbits. The animals were treated with RFA, TAE, SPVE and TAE plus SPVE. Experimental rabbits were divided into four groups: RFA, TAE, SPVE, and TAE plus SPVE. Results ① After treatment, ALT increased most significantly on the first day but decreased most slowly during 4th 7th days in TAE+SPVE group. In RFA group, however, ALT was the lowest on the first day but decreased most rapidly during 4th 7th days. It was markedly lower on the 1st, 4th and 7th days in SPVE group than that in SPVE+TAE group. ② CT scans showed cumulation of lipiodol in the foci in all the 3 vascular embolization groups in the 2nd week. Macroscopic and microscopic observations revealed the tumors became harder after embolization while biopsy demonstrated larger necrotic scope of the foci and much more hyperplastic fibrous tissue in TAE group and TAE+SPVE group than those in SPVE group. However, the necrosis in the vascular embolization groups was incomplete. ③ In the 2nd week after treatment, complete necrotic rate of the foci was significantly higher in RFA group than that in SPVE group and in TAE group. The rate of metastases in lungs was significantly lower in RFA group than that in TAE group. The survival rate was 50% in 3 months in RFA group. Animals in other 3 groups gradually died in 2 months. The average survival time was significantly longer in RFA group than that in other groups. Conclusion SPVE, TAE and SPVE combined with TAE have obvious effect on the vascular embolism of hepatic VX 2 tumor. However, the vascular embolization can not lead to complete destruction of the tumor and may bring about severer injury to the liver. Compared with the methods of vascular embolization, RFA is of better effect and less injury in the treatment of hepatoma in rabbits.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2003年第17期1544-1548,共5页
Journal of Third Military Medical University
基金
重庆市医药卫生领域应用基础研究资助项目 ( 2 0 0 0 8182 )
关键词
射频消融
肝动脉栓塞化疗
选择性门静脉栓塞
肝肿瘤
兔
radio frequency ablation
transcatheter artery embolization
selective portal vein embolization
hepatoma
rabbit
