摘要
目的:探讨遗传性非息肉病性结直肠癌(HNPCC)家系中胃癌的临床特征和在HNPCC家系遴选中的价值。方法:回顾性随访了符合Amsterdam标准(Ⅱ)的6个HNPCC家系和2个胃癌聚集家系,将两组家系中的胃癌特征进行比较。结果:6个符合Amsterdam标准(Ⅱ)HNPCC家系中发现7例胃癌病人,年龄45～72岁。其中胃窦癌4例,胃体癌2例,贲门癌1例,生存时间6～18个月。2个不符合标准Ⅰ但符合标准Ⅱ的家系中,胃癌7例,其中贲门癌4例,胃窦癌2例,胃体癌1例;男性3例,女性4例,年龄45～77岁,生存时间9～37个月。两组病人的年龄、性别和生存时间差异无显著意义,但肿瘤部位差异有显著意义。结论:尽管在国内HNPCC家系中胃癌是主要的肠外肿瘤之一,由于难以与家族性胃癌鉴别,故胃癌不适合列入HNPCC家系的诊断标准。
Objective: To study the the features of gastric cancer patients in hereditary nonpolyposis colorectal cancer(HNPCC) families and to analyse its significance in screening the HNPCC kindreds. Method: Six HNPCC kindreds fulfilled Amsterdam criteria (Ⅱ) and 2 gastric cancer families were followed up retrospectively and the features of the gastric cancer patients found were compared . Results: Seven cases of gastric cancer were found in 6 HNPCC kindreds; their age ranged from 45～72 years; 4 cases had their primary lesion located in the gastric antrum, 1 in the corpus and 1 in the cardial region; their survival time ranged from 6 to 18 mouths. Seven cases of gastric cancer and 1 case of esophageal cancer were found in two gastric cancer families; their age ranged from 45 to 77 years; 2 had their primary lesion located in the antrum, 1 in the corpus and 4 in the cardial area; their survival time ranged from 9 to 37 mouths. The differences of features of gastric cancers found according to these 2 guidelines were not signicanct. Conclusions: Although gastric cancer is the most common extracolonic cancers found in HNPCC families, the cases are not easy to be differentiated from those discovered in gastric cancer families, and thus should not be included in the HNPCC diagnostic criteria.
出处
《外科理论与实践》
2003年第6期482-484,共3页
Journal of Surgery Concepts & Practice
基金
国家自然科学基金资助项目(39970823
30170927)
