摘要
小鼠子宫颈癌(U_(14))移植于成年鼠。新生鼠的背部及爪垫皮下、腹腔。分别于第12h～38d处死行组织学及电镜检查。结果:(1)新生鼠皮下组在移植后第12h已见淋巴管中癌细胞栓,第42h肺泡壁毛细血管中见癌细胞栓,第2～3d肺组织已见明显的癌转移。提示新生鼠皮下移植是癌转移最迅速的动物模型。(2)癌在新生鼠皮下组织侵袭过程中未见明显潜伏期。(3)宿主年龄是癌浸润与转移的重要因素。(4)针吸细胞学检查对腹水癌病例并不安全。
The ascitic tumor cells of U14 were transplanted in adult and newborn mice subcutaneously at footpads and back, or intraperitoneal cavity. All animals were killed on the twelfth hour-the thirty-eighth day, respectively. Histological and TEM studies were made. Results showed : ( 1 )0n the twelfth hour after transplantation, tumor cell emboli were observed in the lymphatic vessels and on the forty-second hour, in the alveolar capillaries, and on the second-third day, pulmonary metastasis was obviously developed. It suggested that the subcutaneous transplantation in the newborn mice be the best model in vivo for studying tumor metastasis. (2)The process of tumor invasion had no marked latency stage. (3)The age was an important factor of tumor invasion and metastasis. (4 )Aspiration cytology was not a safe method for cancerous ascites.
出处
《温州医学院学报》
CAS
1992年第2期63-66,共4页
Journal of Wenzhou Medical College
关键词
子宫颈肿瘤
转移
形态学
淋巴结
uterine cervix
carcinoma metastasis
lung
lymph node
