摘要
本研究分别给四组大鼠注射CCl_4、P_4、TNT及纯生油,进行亚慢性实验,在不同的时间处死动物,测定血清及肝组织NAG、CP、MAO、羟脯氨酸和肝组织病理观察。CCl_4染毒3周后就发生肝纤维化;P_4和TNT染毒12周后才发生肝纤维化。血清中NAG、CP及肝组织中NAG、羟辅氨酸含量在肝纤维化早期即有明显升高,其中血清NAG、CP与肝组织中羟脯氨酸含量有明显正相关关系。血清NAG、CP似可以用作了解肝纤维化情况的指标。
120 male SD rats divied into four groups as CC14, P4, TNT and control were administrated I.P. twice a week for 15 weeks. 5 rats were killed in each group after 3, 6, 9, 12 and 15 weeks of treatment and some biochemical indices were determined. The resuts indicated that the hepatic fibrosis could be produced by CCl4, P4 and TNT. Hepatic fibrosis induced by CCl4 seemed to take place earlier and happened to be more severe than that induced by P4 and TNT. NAG and CP in serum might sensitively reflect the degree of hepatic fibrosis and paralleled to the degree of hepatic fibrosis.
出处
《卫生毒理学杂志》
CSCD
1992年第3期181-183,209,共4页
Journal of Health Toxicology
关键词
肝纤维化
四氯化碳
黄磷
梯恩梯
HePatic Fibrosis
Carbon Tetrachloride
Phosphorus
Trinitrotoluene
Glucosaminidase
Ceruloplasmin
Hydroxyproline.
