摘要
目的探讨调脂对急性冠状动脉综合征(ACS)患者冠脉病变炎症的影响。方法采用随机、单盲、对照方法将125例ACS患者分为辛伐他汀治疗组(n=63)非辛伐他汀治疗组(n=62),另选健康对照组(n=60),测定治疗前、治疗后8周血浆高敏C-反应蛋白(hs-CRP)水平的变化。结果ACS患者的hs-CRP水平明显增高,经辛伐他汀治疗8周后其血浆hs-CRP水平明显下降,非他汀治疗组各项指标无明显变化。结论他汀调脂可阻滞ACS患者冠脉病变的炎症反应。
Objective To investigate the effects of Lipid - Lowering therapy for inflammatory influence of coronary arteriosclerotic lesion in Acute Coronary Syndrome(ACS). Methods 125 patients of ACS were stratified by randomized, single - blind, contrastive assigned to be measured the levels of plasma high sensitive C - reactive protein(hs- CRP) before and after treatment with Simvastatin(20mg/d, for 8 weeks, n - 63)or placebo (n= 62). Results (l)patients with ACS had higher levels of plasma hs- CRP compared with those of control subjects and. (2)The group of simvastatin in patients with ACS significantly reduced plasma hs- CRP, But the placebo group had no change. Conclusion The inflammation of coronary arteriosclerotic lesion with ACS can be blocked by intervention therapy for Lipid- Lowering.
出处
《中国心血管病研究》
CAS
2003年第3期191-193,共3页
Chinese Journal of Cardiovascular Research
