摘要
目的 评估体外循环主动脉阻断期间应用含氧血持续肺动脉灌注对肺功能的保护作用。方法 选择杂种上海犬 (上海农科院犬养殖厂 ) 12只 ,体重 7～ 12kg。随机分成应用含氧血持续肺动脉灌注的实验组和对照组 ,分别测定体外循环前、结束即刻、结束后 1h的肺功能 ,体外循环术后 2组左、右心房内血白细胞记数以及肺水含量的变化。体外循环转流前、后分别在右肺门处随机切取肺组织(3cm× 3cm大小 )送病理检查。结果 术后实验组的肺功能明显改善 ,左、右心房血白细胞记数差异无显著性 ,肺水含量与对照组比较差异无显著意义。对照组显示肺泡间质明显水肿 ,肺泡内大量的中性粒细胞渗出 ,实验组保留了正常的肺组织结构。结论 含氧血持续肺动脉灌注可减轻主动脉阻断期间肺组损伤 ,保护术后肺功能。
Objective: To evaluate the protective effect of pulmonary function of continuous pulmonary perfusion with oxygenated blood during aortic cross-clamp. Methods: Twelve Shanghai mixed-breed dogs (7～12 kg) were divided to two groups. The continuous pulmonary perfusion with oxygenated blood was used in experimental group (group E), the other is the control group (group C). The pulmonary function was detected in the beginning, ending and one hour after cardiopulmonary bypass, respectively. After cardiopulmonary bypass, the white blood cells of both right and left atrium were counted in the two groups and pulmonary water content was measured. Histologic microstructure was compared at the beginning and ending of cardiopulmonary bypass. Results: In group E, the pulmonary function was significantly improved, and there were no significantly changes in white blood cells of both right and left atrium and pulmonary water content after cardiopulmonary bypass. The marked intraalveolar edema and abundant intraalveolar neutrophils appeared in group C. Conclusion: Our study demonstrates the arrested pulmonary circulation during aortic cross-clamp is probably the major risk factor of lung injury and the continuous pulmonary perfusion is effective in preventing lung injury.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2003年第6期360-362,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
