摘要
目的:观察应用长春瑞滨(NVB)、顺铂(DDP)组成NP方案治疗56例晚期非小细胞肺癌(NSCLC)的疗效和不良反应。方法:NVB 25-35 mg/m2,静脉注射,第1、8天;DDP 40-50 mg/m2,静脉滴注,第1、2、3天。21天为1周期,连用2-3个周期。结果:完全缓解(CR)5例,部分缓解(PR)21例,无变化(NC)22例,进展(PD)8例。该方案主要毒性反应为白细胞下降.Ⅲ、Ⅳ度白细胞下降为48.2％,但无1例因感染而死亡。结论:采用NP方案治疗晚期NSCLC的有效率较高,不良反应可耐受.可作为临床治疗晚期NSCLC的一线方案。
Objective: To evaluate the results of combination chemotherapy with vinorelbine(NVB) and cispl-atin(DDP)in patients with advanced non-small lung cancer (NSCLC). Methods: Fifty six cases of advanced NSCLC were treated with NP regimen in this study. Results: Response rate(RR) was observed in 46. 5% of patients,the main toxicity was neutropenia,which was grade III and IV in 48.2% of patients. Conclusion: The combined regimen of NP for treating advanced NSCLC has a high response rate and tolerable side effects . It can be used as the first line regimen for treating advanced NSCLC.
出处
《江苏大学学报（医学版）》
CAS
2003年第6期506-507,共2页
Journal of Jiangsu University：Medicine Edition
关键词
非小细胞肺癌
化学治疗
长春瑞滨
顺铂
Non-small lung cancer
Chemotherapy
Vinorelbine
Cisplatin
