摘要
自1991年4月至1995年2月,作者应用HEF化疗方案治疗进展期胃癌患者60例,其中38例为复治者,22例为初治者。方法是羟基喜树硷(HCPT)4mg/m^2/d,iv d;鬼臼乙叉甙(VP—16)60mg/m^2/d,VD d1—5;5—氟脲嘧啶(5—Fu)600mg/m^2/d,VD d1—5,4周重复1次,应用2～3个疗程后判定效果,5例达完全缓解(8.3％),29例达部分缓解(48.4％),总有效率56.7％。中位生存期8.5个月。毒副反应小,主要为消化道反应、脱发和骨髓抑制。
From Apr. 1991 to Feb. 1995. HEF Combined Chemotherapy was administered to 60 patients with advanced gastric cancer. Among the 60 patients, thirty eight had received prior chemotherapy and twenty-two were previously untreated. HEF chemotherapy consists of Hydroxycamptothecine (HCPT) with 4mg/m2/day iv for 10 days, Etoposide (VP-16) with 60mg/m2/day VD, for 5 days and Fluorouracilum (5-Fu) with 600mg/m2day VD, for 5 days. Cycles repeated for 28 days. After 2 to 3 courses treatment, five patients achieved a complete response (8. 3%) .twenty -nine patients had a partial response(48. 4%). The mean time of survival was 8. 5 months. Toxicity generally was mild and separated into the digestive tract reaction and the alopecia or the hematological effects.
出处
《临床肿瘤学杂志》
CAS
1996年第1期34-35,共2页
Chinese Clinical Oncology
