摘要
目的 :观察糖尿病大鼠合并肾病病变时其血浆内皮素 (ET)含量的变化。方法 :复制糖尿病大鼠合并肾病模型 (DN ) ,采用放射免疫分析法 ,于实验的第 1、2、4周 ,测定血浆内皮素含量。结果 :第 1周时各组血浆内皮素值无明显差异 (P >0 .0 5 ) ,第 2、4周时 ,DN组显著高于胰岛素治疗组 (INS组 ) (P <0 .0 5 )和正常组 (NC组 ) (P <0 .0 5 ) ,但 INS组与 NC组之间无显著性差异 (P >0 .0 5 )。结论 :内皮素与 DN的发生和发展有密切关系 ,内皮素是介导
Objective: To investigate the concentration of plasma endothelins (ET) in rats with diabetic nephropathy (DN). Methods: We prepared DN models, and tested the concentrations of plasma ET at weeks 1,2 and 4 by EIA.Results:the concentration of plasma ET didn′t appeared to be intensified when compared with each group during 1 week (P>0.05). DN group appeared to be intensified when compared with group treated by insulin (INS group)(P<0.05) and normal control group (NC group) (P<0.05), but had no notable difference between INS group and NC group (P>0.05). Conclusion: ET and DN have close relationship with each other,and ET is an important medium in DN development.
出处
《黑龙江医药科学》
2003年第6期20-20,共1页
Heilongjiang Medicine and Pharmacy
