摘要
低剂量辐射(lowdoseradiationLDR)可以增强细胞对随后进行的攻击性剂量(challengedose)照射的抵抗能力,从而降低攻击性照射引起的染色体畸变和DNA损伤。人们把LDR的这种效应称之为“低剂量辐射诱导的适应性反应”。低剂量辐射诱导适应性反应的分子机制主要涉及细胞信号转导、ROS活性氧物质的作用和DNA修复兴奋效应等方面。
Adaptive response is a term used to describe the ability of a low, priming dose of ionizing radiation to modify the effects of a subsequent higher, challenge dose. Molecular mechanism of adaptive response to low dose radiation is involved in singal transduction pathway, reactive oxygen species, DNA damage repair.
出处
《国外医学（放射医学核医学分册）》
2003年第6期276-278,共3页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
基金
天津市自然科学基金资助项目(023611111)
关键词
低剂量辐射
适应性反应
信号转导
活性氧物质
DNA修复
low dose radiation
adaptive response
singal transduction pathway
reactive oxygen species
DNA damage repair
