摘要
本实验测定了慢性血吸虫病家兔(n=11)肝组织的SOD活性,观察了肝超微结构改变。结果:病兔组肝SOD活性为2113U/g,明显低于正常组(n=7)的4162U/g(P<0.01).透射电镜发现,病兔肝细胞的超微结构有不同程度的损伤,肝窦内皮细胞崩解、破裂,窦壁粘附有自细胞,并使窦腔狭窄。研究结果表明。
It is currently believed that free radicals can induce injury to liver. In the present experiment, we measured the liver SOD activity in rabbits (n=11) with chronic schistosomiasis and observed the liver ultrastructural changes. The results showed that the SOD activity in schistosomiasis group decreased significantly, compared with that in the control group (n = 7) (2113 Vs 4162, P<0.01).The electron microscopic examination revealed that the ultrastructure of hepatocyte and sinusoidal endothelium was destroyed, with leukecyte adherence in sinusoidal wall and stenosis of sinusoidal cavaty. These findings suggest that free radical reaction is an important cause of damage to liver ultrastructure with schistosomiasis.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1992年第6期361-363,共3页
Acta Universitatis Medicinae Tongji
关键词
自由基
兔
血吸虫病
肝
超微结构
free radical
rabbit
schistosomiasis
liver
ultrastructure
