摘要
目的 考察自制硝苯地平缓释微丸的体外释药机制。方法 按中国药典 (2 0 0 0版 )浆法 ,进行体外释放度测定 ,累积释放度数据经计算机处理。结果 本文自制硝苯地平缓释微丸为亲水性凝胶骨架制剂 ,体外释放机制包括药物扩散和骨架溶蚀两种作用。结论 自制硝苯地平缓释微丸体外缓释 ,有进一步开发的价值。
Aim To inspect the release mechanisms of nifedipine sustained-release beads in vitro.Methods According to the plasm method of Chinese Pharmacopeia (2000),the dissolution was determined and the accumulated dissolution data was processed.Results The nifedipine sustained-release beads was hydrophilic gel frame,drug diffusion and frame erosion was the release mechanisms in vitro.Conclusion The nifedipine sustained-release beads was sustained-release in vitro and was worthy of being deueloped.
出处
《解放军药学学报》
CAS
2003年第6期424-426,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
硝苯地平
缓释微丸
体外释药机制
药物
血药浓度
Nifedipine
Sustained-release beads
Na-alginate
Release mechanisms
In vitro
