摘要
目的 :探讨参麦注射液对充血性心力衰竭 ( CHF)患者血浆内皮素 ( ET)和血清肿瘤坏死因子 - α( TNF- α)的影响。方法 :将 CHF患者 1 32例随机分为 A组 ( 72例 )和 B组 ( 60例 ) ,A组在常规治疗基础上加用参麦注射液 ,B组采用常规治疗 ,疗程 2周。另设 30例健康成人对照组。治疗前后用放射免疫分析法分别测定血浆 ET和血清 TNF- α浓度。结果 :CHF患者的 ET、TNF- α浓度较对照组明显升高 ( P<0 .0 1 ) ;心功能 NYHA 级者的 ET、TNF-α浓度较 级和 级者都有明显升高( P<0 .0 1 ) ;A、B两组治疗后 ET、TNF- α浓度较治疗前有明显下降 ( P<0 .0 5或 P<0 .0 1 ) ,但 A组较 B组下降更明显 ( P<0 .0 5 )。结论 :参麦注射液可通过降低血浆 ET和血清 TNF-α水平改善心功能。
Objective: To study the effect of Shenmai injection on the levels of plasma ET and serum TNF-α in hyperemia heart failure(HHF) patients.Methods:132 cases of HHF were randomly divided into A group(72 cases) and B ground(60 cases).A group was treated by normal medicine combined with Shenmai injection,B group by normal group only,both with a treatment period of 2 weeks.And 30 cases of normal aged were chosen as control group.The levels of plasma ET and serum TNF-α were checked by raido-immune assay methods before and after treatment.Results: The levels of ET and TNF-α in cases with HHF were higher than those in control group(P<0.01) ;The levels of ET and TNF-α in cases with Ⅳ class of heart function were highter than those with Ⅱ and Ⅲ class of heart function(P<0.01);The levels of ET and TNF-α in both A and B groups after treatment were lower than those before treatment(P<0.05 or P<0.01),while those in A group decreased more significantly than in B group(P<0.05). Conclusion:Shenmai injection can impreove the heart function by decrease plasma ET and serum TNF-α in hyperemia heart failure(HHF) patients.
出处
《浙江中西医结合杂志》
2004年第1期4-6,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
