摘要
目的 探讨肝细胞癌(HCC)所致的胆管梗阻的影像特点,评估通过ERCP治疗此类患者的疗效。方法 从2000年5月至2003年3月,292例因HCC所致的梗阻性黄疸患者共行ERCP诊疗358例次。患者年龄(51.9±10.6)岁,术前血清总胆红素为(232±158)μmol/L。ERCP时记录下其胆管影像特点,260例接受了内镜下治疗,治疗方法包括括约肌切开及胆管内坏死组织清除、鼻胆管引流术、塑料或金属支架置入和多方法联合应用。观察术后2周内患者体温、胆汁引流量和肝功能的变化,依据这些指标确定疗效。结果 根据放射影像的特点,将患者分成5种类型:Ⅰ型为肝内胆管狭窄或梗阻型(5.9％)、Ⅱ型为肝门部狭窄或梗阻型(19.0％)、Ⅲ型为肝外胆管狭窄或梗阻型(18.4％)Ⅳ型肝门部胆管内癌栓型(49.4％)和Ⅴ型胆管内游离瘤栓型(7.3％)。267例次治疗后患者接受随访,黄疸症状得到有效控制者占82.0％,其中血清胆红素显著降低者为 65.5％。结论 ER-CP对于诊断和姑息性治疗HCC引起的梗阻性黄疸具有积极作用。
Objective To discover the features of biliary obstruction in hepatocellular carcinoma (HCC) and evaluate the effectiveness of therapeutic ERCP in the management of such patients. Methods Two hundred and ninety two patients (male 234 and female 58) suffering from HCC with obstructive jaundice underwent 358 times of ERCPs between May 2000 and March 2003. The mean (SD) age and mean (SD) total serum bilirubin of these patients were 51. 9 ±10. 6 yrs and 232 ± 158μmol/L respectively. The profiles of cholangiographic changes were recorded. Two hundred and sixty cases received treatment under endosco-py. Then therapeutic techniques including sphinclerotomy and debris removal, naso-biliary drainage, plastic or metal stent placement or several procedures in combination were given to all patients except 32 cases in far advanced condition. The body temperature, amount of bile drained and changes in liver function test were observed within two weeks post-procedure and based on these data the therapeutic effectiveness was evaluated. Results According to the features of radiographic finding, five types of biliary obstruction were classified as: type Ⅰ - intrahepatic stricture or occlusion (5.9%); type Ⅱ - perihilar stricture or occlusion (19. 0% ) ; type Ⅲ - extrahepatic stricture or occlusion (18. 4% ) ; type Ⅳ - hilar intraductal tumor em-bolus (49. 4% ) ; and type Ⅴ - intraductal floating tumor debris (7. 3% ) . In 267 patients/times under follow-up, the symptomatic jaundice was improved in 82. 0% of the patients with significant reduction of serum bilirubin in 65. 5%. Conclusion ERCP plays an important role in both diagnosis and palliative management of the HCC patients with obstructive jaundice.
出处
《中华消化内镜杂志》
2003年第6期367-370,共4页
Chinese Journal of Digestive Endoscopy
关键词
肝细胞癌
梗阻性黄疸
ERCP
诊断
治疗
Carcinoma, hepatocellular
Jaundice
Cholangiopancreatography, endoscopic ret-rograde
