摘要
目的 探讨葛根素对链脲菌素诱导的糖尿病大鼠血液流变学的影响。方法 以链脲菌素 (STZ)造成糖尿病 (DM)模型大鼠 ,将造模大鼠按血糖值随机分为模型组、葛根素组 (50 0 ,2 50 ,12 5mg·kg 1,ig) ,另设一正常对照组 ,连续灌胃给药 12周。于给药后 8周、12周 ,以葡萄糖氧化酶法分别检测血糖 ;12周时检测血液流变学指标。结果 葛根素可明显降低STZ诱导的DM大鼠异常升高的血糖 ,与DM组比较差异显著 (P <0 .0 1) ;血液流变学的各项指标与DM组比较均有显著性差异 (P <0 0 5)。结论 葛根素可通过降低血糖 。
Objective To assess the effects of puerarin on blood rheology of streptozotocin-induced diabetic rats.Methods Rats were induced by streptozotocin(STZ) as diabetic ones,and then were d ivided randomly into four groups:diabetic mellitus(DM),pue 1(0.5g·kg - 1 ,ig.),pue 2(0.25g·kg -1 ,ig.),pue 3(0.125g·kg -1 ,ig.) ,and a normal group additionally.The blood glucose was measured at the eighth and twelfth week.The rehologic indexes of diabetic rats on twelfth week compar ed with DM group.Results Puerarin could lower the levels of bl ood glucose of the diabetic rats,and all of the parameters related to the blood rheology of STZ-induced diabetic rats showed significances compared with DM g roup( P <0.05).Conclusion Through decreasing blood glucose ,improving indexes of blood rheology in diabetic rats,puerarin could be ben eficial to control the development of diabetes mellitus and its complications.
出处
《中国血液流变学杂志》
CAS
2003年第4期322-324,共3页
Chinese Journal of Hemorheology
基金
江苏省中医药管理局科研基金资助项目 (H 0 2 8)
