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游离脂肪酸抑制葡萄糖刺激的胰岛功能 被引量：2

Free fatty acids inhibit glucose-induced islets function
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摘要 目的　研究高糖条件下游离脂肪酸对胰岛功能的影响。方法　利用胰岛体外培养方法及RT PCR技术 ,检测胰岛素分泌和前胰岛素原mRNA的表达。结果　游离脂肪酸组胰岛素的分泌和前胰岛素原mRNA的表达均减少。 Objective To observe the effect of free fatty acids on glucose induced insulin secretion and synthesis.Methods Insulin levels and preproinsulin mRNA expression were analysed by RT PCR and incubated in vitro. Results Preproinsulin mRNA expression and insulin levels were depressed in the FFA groups.Conclusion Free fatty acids inhibit glucose induced insulin secretion and synthesis.
作者 乔虹 李强
机构地区 哈尔滨医科大学第二临床医学院内分泌代谢病科
出处 《哈尔滨医科大学学报》 CAS 2003年第6期494-496,共3页 Journal of Harbin Medical University
关键词 游离脂肪酸 抑制葡萄糖刺激 胰岛功能 RT-PGR技术 胰岛素 free fatty acids insulin preproinsulin glucose RT PCR
分类号 R335.6 [医药卫生—人体生理学]
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参考文献8

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同被引文献19

  • 1毛微波,郭晓蕙,高妍,童玉,唐朝枢.Ghrelin促进大鼠胰岛素合成及高葡萄糖诱导的胰岛素分泌[J].基础医学与临床,2004,24(4):432-435. 被引量：12
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哈尔滨医科大学学报
2003年 第6期

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