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TGF-β/Smad与妇科恶性肿瘤发生发展关系的研究进展 被引量：1

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摘要 转化生长因子 β(TGF β)信号转导通路功能异常与妇科恶性肿瘤的发生和发展密切相关 ,现就TGF β信号转导通路 ,尤其是Smad在妇科恶性肿瘤发生发展中的研究进展 。
作者 纪国欣 王欣 赵兴波
机构地区 山东大学山东省立医院
出处 《现代妇产科进展》 CSCD 2003年第6期447-449,共3页 Progress in Obstetrics and Gynecology
关键词 转化生长因子Β 生殖器肿瘤 女性 信号转导通路 研究进展 肿瘤分子生物学
分类号 R737.3 [医药卫生—肿瘤]
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参考文献20

  • 1[1]Piestrzeniewicz-Ulanska D,Brys M,Semczuk A,et al. Expression of TGF-β type Ⅰ and Ⅱ receptors in normal and cancerous human endometrium[ J]. Cancer Lett, 2002,186: 231-239
  • 2[2]Itoh S, Itoh F, Goumans MJ, et al. Signaling of transforming growth factor-beta family members through Smad proteins[J].Eur J.Biochem, 2000,267:6954-6967
  • 3[3]Maurice D, Pierreux CE, Howell M, et al. Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stsbility[ J] .J Bilo Chem,2001,276:43175-43181
  • 4[4]Wu HS, Li YF, Chou CI, et al. The concentration of serum transforming growth factor beta-1(TGF-beta1) is decreased in cervical carcinoma patients[J]. Cancer Invest,2002,20:55-59
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  • 6[6]Lee S,Cho YS, Shim C,et al. Aberrant expression of Smad4 results in resistance against the growth-inhibitory effect of transforming growth factor-β in the SiHa human cervical carcinoma cell line[J] .Int J Cancer,2001,94:500-507
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  • 8[8]Chatzaki E,Kouirtzoglou E,Margioris AN,et al. Transforming gowth factor betal exerts an autocrine regulatory effect on human endometrial stromal cell apoptosis, involving the FasL and Bcl-2 apoptotic pathways[J] .Mol Hum Reprod, 2003,9:91-95
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同被引文献13

  • 1Tsuru M, Nagata K, Ueno T, et al. Confocal laser microscopy of chondrocytes that received gene transfer using in vitro electroporation[ J ]. Kurume Med J ,2002,49 : 1-5
  • 2Piestrzeniewicz-Ulanska D, Brys M, Semczuk A, et al. TGF-beta signaling is disrupted in endometrioid-type endometrial carcinomas [ J ]. Gynecol Oncol,2004,95 : 173- 180
  • 3Kretschmer A, Moepert K, Dames S, et al. Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4 [ J ]. Oncogene,2003 ,22 :6748-6763
  • 4Moren A, Hellman U, Inada Y. Differential ubiquitination defines the functional status of the tumor suppressor Smad4 [J]. J Biol Chem,2003 ,278 :33571-33582
  • 5Parekh TV, Gama P, Wen X,et al. Transforming growth factor beta signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition[J]. Cancer Res,2003,62:2778-2790
  • 6Chatzaki E, Kouimtzoglou E, Margiofis AN, et al. Transforming growth factor betal exerts an autecrine regulatory effect on human endometrial stromal cell apoptosis, involving the FasL and Bcl-2 apoptotic pathways[ J ]. Mol Hum Reprod,2003,9:91-95
  • 7Lee S, Clio YS, Shim C, et al. Aberrant expression of Smad4 results in resistance against the growth-inhibitory effect of transforming growth factor-β in the SiHa human cervical carcinoma cell line [ J ]. Int J Cancer,2001,94 : 500-507
  • 8Hecevar BA, Howe PH. Mechanisms of TGF beta induced cell cycle arrest [ J ]. Miner Electrolyte Metab, 1998,24 : 131-135
  • 9Sola S, Ma X, Castro RE, et al. Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspaseindependent mechanism in transforming growth factor betal-induced apoptosis of rat hepatocytes [ J ]. J Biol Chem,2003 ,278 :48831-48838
  • 10Akiyoshi S, Ishii M, Nemoto N, et al. Targets of transcriptional regulation by transforming growth factor: expression profile analysis using oligonucleotidc arrays jpn [J]. J Cancer Rcs,2001,92 :257-268

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现代妇产科进展
2003年 第6期

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