摘要
目的 :调查冠心病患者发生阿司匹林抵抗 (AR)的发生率和流行病学特征 ,并探讨其相关因素。方法 :病情稳定的冠心病患者 2 0 9例 ,每日服用阿司匹林 10 0 mg,连服 7d,服用最后一剂后 2 4h内抽取空腹静脉血 ,分别用二磷酸腺苷 (ADP)、花生四烯酸 (AA)诱导血小板凝集试验 (PAg T) ,检测血小板聚集率。结果 :患者中 AR发生率为3 .8% ,阿司匹林半敏感 (ASR)者占 2 5.8% ,且 AR或 ASR患者中的女性比率较阿司匹林敏感者 (AS)高 (P <0 .0 5) ,而 AS者中吸烟者较 AR或 ASR者多 (P<0 .0 1)。结论 :阿司匹林用于抗血小板治疗及预防动脉硬化事件的冠心病患者可产生 AR,预测 AR及抗血栓治疗个体化 。
AIM: To invastigate the prevalence of aspirin resistanc e (AR) in the pa tients with cardiovascular disease and further clarify the clinical predicto rs. METHODS: The patients with stable cardiovascular diseases who wer e re ceiving 1 00 mg/daily of aspirin for 7 days, but no other antiplatelet agent .T heir blood samples were analyzed for AR by platelet aggregation test(pAgT) using ade nosine diphosphate(ADP) and arachidonic acid(AA). RESULTS: 3.83% of th e patients showed AR and 25.8% of them showed aspirin semiresponders(ASR). Patie nts who were either AR or ASR were more likely to be women ( P <0.05) and less likely to be smokers ( P <0.01) compared with aspirin-sensitive patients. CONCLUSION: The finding of AR could be of particular importance, given the large mumber of patients relying on this medicati ons for antiplatelet protection. Now that there are so many safe alternative ant i-platelet agents available for longterm administration, to identify patient with aspirin resistance appears to be of great help in trating patients with cardiovascular disease.
出处
《心脏杂志》
CAS
2003年第6期534-536,共3页
Chinese Heart Journal
