摘要
目的 研究高血压病患者血浆纤维蛋白原及载脂蛋白及异常形态红细胞变化特点及其与腔隙性脑梗塞 (腔梗 )的关系。方法 选择正常对照组 40例、高血压病组 45例和高血压腔隙性脑梗塞组 (腔梗组 ) 48例患者 ,分别测定血浆纤维蛋白原、载脂蛋白A(apoA)、载脂蛋白B(apoB)和血脂水平 ,并用扫描电镜观察了红细胞形态。结果 (1)腔梗组血浆纤维蛋白原显著高于对照组与高血压病组 (P <0 0 1)。 (2 )腔梗组载脂蛋白A显著低于对照组与高血压病组 (P<0 0 1) ;腔梗组载脂蛋白B及载脂蛋白B/A比值显著高于对照组 (P <0 0 1)。 (3 )腔梗组平均异常形态红细胞检出率及异常形态红细胞增高率和脂蛋白B/A比值 >1的检出率均明显高于对照组及高血压病组 (P <0 0 1)。结论 血浆纤维蛋白原增高参与高血压病及高血压腔隙性脑梗塞的发生和发展 ,并提示血浆纤维蛋白原增高的程度可能预示病情程度。载脂蛋白A减低、载脂蛋白B增高与血浆纤维蛋白原增高有相似趋势 。
Objective To investigate the relationship between plasma f ib rinogen, apolipoproteins and abnormal erythrocyte in patients of hypertensive co mplicated with lacular infarction. Methods Fourty normal volunteers, 45 patients with hypertension and 48 patients with hypertensive lacular infarction group were recruited. Serum plasma fibrinogen and apolipoproteins were measured. Erythrocyte morphology was assessed by scanning electronic microscope. Results (1) Plasma fibrinogen was higher in hypertensive lacular infarction group than those in hypertension alone group and normal group(P<0 01). (2) Apolipoprotein A was lo wer in hypertensive lacular infarction group than those in hypertension alone and normal group(P<0 01); (3) the prevalance rate of abnormality of erythrocyte, and apolipoprotein B/A ratio >1 were higher in hypertensive lacular infarction group than those in normal group(P<0 01). Conclusion (1) Plasma Fi brinogen may involved in the occurrence lacular infarction in hypertension payti ents. The increased level of plasma fibrinogen could predicate the severity of the patients with hypertension. (2)The decrease of apolipoprotein A and increase of apolipoprotein B was associated with the increase of plasma fibrinogen, be related with abnormal erythrocyte in hypertension patients with lacular infarction.
出处
《高血压杂志》
CSCD
2003年第6期548-551,共4页
Chinese Journal of Hypertension
