摘要
目的 评价缬沙坦治疗轻中度高血压的降压疗效 ,对性功能的影响及安全性。方法 开放 ,多中心试验设计。对轻中度原发性高血压患者进行缬沙坦治疗前后血压水平、性功能指标的比较 ,并观察治疗中的不良反应。结果 缬沙坦治疗 8周后 ,坐位收缩压降低 19 5mmHg ,舒张压降低 13 9mmHg ,总有效率 86 9%。治疗后男女高血压患者性功能指标均有不同程度改善 ,尤以男性明显。 40岁以上中老年患者性功能指数升高更显著。治疗中无体位性低血压和严重不良事件发生。结论 缬沙坦降压疗效确切 ,不良反应少 ,可改善性功能 。
Objective To evaluate the impact of valsartan on sexual function in essential hypertension. Methods Open, multi-centers clinical observation was carried out in 191 patients. Blood pressure levels and parameters of sexual function of hypertensive patients were assessed before and after valsartan treatment for 8 weeks. Side effects were observed in the treatm ent period. Results Sitting systolic blood pressure was decreased by 19.5 mmHg, total response rate was 86.9%. Sexual function was improved in both male and females, especially that in males. More significant improvement of sexual function scorces were observed in patients older than 40 years. No postual hypotension and severe side effects were found. Serum potassium was increased mildly with no clinical significance. Conclusion Valsartan decreased blood pressure eff ectively with few side effects. The fact that valsartan improved sexual function in old patients of hypertension suggested it was especially suitable for aged patients.
出处
《高血压杂志》
CSCD
2003年第6期540-542,共3页
Chinese Journal of Hypertension
