摘要
我们采用9×9拉丁方设计在犬实验性心力衰竭模型,观察比较了6种常用血管扩张剂单独或联合应用的效果。9只犬分别接受9种治疗方式,包括1.空白对照,2.硝普钠,3.酚妥拉明,4.消心痛,5.甲巯丙脯酸,6.甲巯丙脯酸加用消心痛,7.硝苯吡啶,8.硝苯吡啶加用消心痛,9.哌唑嗪。结果显示,这些药物均能产生良好的血液动力学效应,均能改善左室舒张性能,其中又以甲巯丙脯酸疗效最佳。
A 9×9 latin square design was employed for comparing the effects of 1. pla-cebo, 2. nitroprusside, 3. phentolamine, 4. isosorbide dinitrate, 5. captopril, 6. cap-topril-isosorbide dinitrate combination, 7. nifedipine, 8. nifedipine-isosorbide dini-trate combination and 9. prazosin in 9 dogs with heart failure caused by pituitrin.The consistent changes caused by these drugs were the improvements of hemodyna-mics and left ventricular diastolic function. Of the vasodilators, the most satisfac-tory effect was found in captopril administration.
出处
《天津医药》
CAS
1992年第8期456-458,共3页
Tianjin Medical Journal
关键词
心力衰竭
血液动力学
血管扩张药
vasodilator
heart failure
pituitrin
hemodynamics
diastolic function
