摘要
本文研究58例45岁以上非胰岛素依赖性糖尿病(NIDDM)病人的垂体-性腺轴水平改变及其心血管并发症的关系,发现NIDDM患者的垂体促性腺激素(FSH、LH)增高,男性睾酮(T)降低,雌二醇(E_2)和E_2/T值明显增高,并发心血管病变时则改变更明显。女性患者则E_2、E_2/T值明显减低,并发心血管疾病时这种改变更显著。垂体-性腺轴水平的变化对性激素内环境稳定性改变具有重要意义,性激素内环境失衡易致糖尿病心血管并发症。
Changes of pituitary-gonad axis and relationship between them and cardiovascu-lar complication of diabetes were studied in 58 patients type Ⅱ diabetics aged hig-her. The results suggested that the levels of serum FSH, LH increased; in men serumtestosterone (T) decreased, estradiol (E2) and E2/T ratio markedly increasedwhen changes of patients with cardiovasular complication were significant; in womenE2. E2/T ratio markedly decreased, in diabetics with cardiovascular complicationwere most significantly. The changes of pituitary-gonad axis in diabetes were significant in causingimbalance of the hormonal internal environment, which could easily lead to thedevelopment of diabetic cardiovasular complications.
出处
《天津医药》
CAS
1992年第2期83-86,共4页
Tianjin Medical Journal
关键词
II型
糖尿病
垂体-性腺轴
NIDDM
type Ⅱ divbetics
cardiovascular complication
pituitarygonad axis
T E_2
E_2/T ratio
