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纳洛酮对感染性休克病人心、肾功能损害的防治作用

Naloxone's Prevention and Cure of Heart and Kidney Damage to Infectious Patients Suffering from Shock
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摘要 目的:探讨纳洛酮对感染性休克病人脏器损害的防治作用。方法:41例感染性休克病人按不同用药方法分为A(n=20)和B(n=21)组进行治疗,两组均常规抗休克,B组加用纳洛酮治疗。观察休克当日、2、3、5、7和10d的心肌酶谱、肾功能变化及休克期内(48 h)尿量的变化。结果:B组治疗后尿量显著增加;两组心肌酶谱、肾功能各项指标均显著升高,但B组显著低于A组。结论:对感染性休克病人使用纳洛酮可以减轻心、肾功能的损害。 Objective: This thesis discusses naloxone's prevention and cure of heart and kidney damage to infectious patients suffering from shock. Methods: 41patients being treated are divided into group A (n=20) and group B (n=21) according to different medication. 2 groups are regularly anti-shock, and then treat group B with naloxone. After observations of day 1,day 2,day 3,day 5,day 7, day 10 heart muscle enzyme, functional change of kidneys, and amount of urine during the shock. Results: Group B's urine increase after being treated, indications like heart muscle enzyme, kidney functions of the 2 groups clearly rise a lot, but group B is lower than group A. Conclusion: Treating patients suffering from shock with naloxone can alleviate the damage to the heart and kidney.
出处 《岭南急诊医学杂志》 2003年第3期182-183,185,共3页 Lingnan Journal of Emergency Medicine
关键词 纳洛酮 感染性休克 肾功能 心功能 临床资料 治疗 naloxone infectious shock heart function kidney function damage
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参考文献3

  • 1Clayton H,shateny JF,Robert M,et al.Endogenous opioid activity in clinical hemorrhagic shock[].Surgery Gynecology and Obstetrics.1985
  • 2Solani L,Guibotti A.Opiate receptor-mediated inhibition of catecholamine release by primate cultures of booine adrenal canine hypovolemic shock[].Circulatory Shock.1985
  • 3Kogama S,Santiesteban HL,Ammons WS,et al.The effects of naloxone on the peripneral sympathytics in cat endotoxin shock[].Cric Shock.1983

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