摘要
为探讨拉米夫定对慢性乙型肝炎的临床治疗效果 ,将 114例慢性乙型肝炎患者随机分为治疗组及对照组 ,两组均使用保肝及对症综合治疗 ,治疗组同时给予拉米夫定片剂 ,10 0 mg.d- 1 ,疗程 1年。 HBV-DNA阴转、HBe Ag/HBe Ab转换和 ALT正常为有效指标。结果显示 ,拉米夫定能抑制 HBV-DNA的复制 。
To investigate the therapeutic effects of lamivudine on chronic hepatitis B. While being treated with liver protecting medicines and routine treatments, 114 patients with chronic hepatitis B were randomized into tow groups, in which 62 patients received lamivudine 100mg once daily for one year. The end points were HBV DNA reducing to negative, HBeAg transforming to HBeAb , and ALT levels being normalized. In 47 of 62 patients received lamivudine (75.8%), lamivudine treatments resulted in significant effects. Lamivudine inhibits the duplication of HBV DNA and exhibits therapeutic effects on treating chronic hepatitis B.
出处
《数理医药学杂志》
2004年第1期52-53,共2页
Journal of Mathematical Medicine
