摘要
镉作为一种有毒的环境污染物 ,可对机体的多种器官和组织造成损伤。镉的毒作用机制十分复杂 ,其中镉引起的细胞钙稳态失调是镉造成机体损伤的一个重要方面 ,也是当今镉毒作用机制研究的热点。本文就镉影响细胞内钙稳态调节机制 ,引起细胞钙超载后激活蛋白激酶C 。
As a poisonous environmental pollutant,cadmium can cause damage in many organs and tissues.The mechanism of cadmium toxicity is very complicated,in which cadmium induced disturbance of intracellula calcium homeostasis is an important aspect of its body injury,as well as current research focus on cadmium.Effect of cadmium on regulation of intracellula calcium homeostasis,and interference of activation of protein kinase C by intracellular calcium overload with intracellular calcium related message transfer system were reviewed in this paper.
出处
《中国工业医学杂志》
CAS
北大核心
2003年第6期351-354,共4页
Chinese Journal of Industrial Medicine
基金
国家自然科学基金资助 (编号 :30 371 2 0 0 )
关键词
镉
细胞钙
相关酶活性
钙调蛋白
蛋白激酶C
Cadmium
Calmodulin
Ca 2+ ATPase
Na + K + ATPase
Protein kinase C
