摘要
目的探讨丙型肝炎病毒(HCV)的垂直传播机制。方法选择6对抗-HCV与HCV RNA均阳性的母亲与胎儿,2对父亲抗-HCV与HCV RNA阳性、母亲阴性的胎儿为研究对象,检测父、母亲与子代HCV的感染标志,同时比较两代间所携HCV的基因型别与HCV C/E1区的序列同源性。结果6对母亲与胎儿HCV RNA阳性,基因型均一致,其中5对基因型别属Ⅱ型,1对属Ⅲ型。母亲与子代间所携HCV C/E1区的序列同源性极高,与其他母亲间、胎儿间的HCV同源性显著差异。2对父亲HCV RNA 阳性其胎儿未检测到HCV RNA。结论母亲与子代间存在出生前期的HCV的垂直传播。
Objective To investigate the mechanism for vertical transmission of hepatitis C virus (HCV) infection. Methods This study included 6 pairs of mothers and fetuses who were positive for anti-HCV antibody and HCV RNA, and 2 pairs offathersandfetusinwhomthefatherwaspositiveforanti-HCVandHCVRNAwhilethemotherwasnegative.HCVgenotypes were detected by PCR and the nucleotide sequences of HCV genome spanning the core and envelope gene region (HCVC/E1)determinedandcompared.Results TheHCVgenotypesofthemothersandfetuswereconsistent.Fivemother-fetus pairs were of genotype II, 1 of genotype III, with high homology of HCV between the mothers and their ownfetuses. In contrast, in the two father-fetus pairs, no HCV RNA was detected in the fetuses in spite of the positivity of thefathers. Conclusion Vertical transmission of HCV infection from mothers to fetus is a clinical entity.
出处
《第一军医大学学报》
CAS
CSCD
北大核心
2003年第12期1290-1292,共3页
Journal of First Military Medical University
基金
广东省科委资助课题(97002)~~
